1/26/2024 0 Comments Free instals Zotero 6.0.27We examined GsONC201 and show that it is the active angular isomer, formulated as a free base as opposed to ONC201 which is a dihydrochloride salt, and increased survival of a DIPG PDX model. Commercial access to a synthesized version of ONC201 (GsONC201) is available in Germany however, no information is available about its formulation, bioavailability, or efficacy, compared to ONC201 (Oncoceutics). However, access to ONC201 is limited to patients in the United States and Japan. Recently, clinical studies testing ONC201 in glioblastoma and in DIPG case studies suggest a therapeutic benefit for patients who harbor H3K27M mutations, encouraging clinical trials in DIPG where the mutation is seen in more than 80% of cases. To date, all clinical trials for children diagnosed with DIPG have failed to increase median overall survival, which remains 9–11 months.
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